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Diabetic Retinopathy Models and BPC-157 Diabetic retinopathy (DR) involves a cascade of microvascular and neuronal pathology: pericyte loss (early hallmark, precedes endothelial dysfunction), BRB breakdown (tight junction protein claudin-5/occludin/ZO-1 loss), microaneurysm formation, acellular capillary development, and ultimately neovascularisation in proliferative DR

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